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Yellow fever vaccine

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What is yellow fever?

Yellow fever is a serious disease caused by a virus spread by infected mosquitos, although it can’t be spread directly from person to person. Symptoms of the disease begin with fever, headache, chills and nausea or vomiting, and can progress to jaundice (yellow skin or eyes), liver, kidney, respiratory failure and death. Yellow fever occurs mainly in certain parts of Africa and tropical South America.

Frequently Asked Questions

The yellow fever vaccine can prevent yellow fever. It’s given as a single shot at least 10 days prior to travel. Booster shots are recommended for people who remain at risk.

The yellow fever vaccine is only administered at approved vaccination centers that can provide the traveler with a valid International Certificate of Vaccination or Prophylaxis (ICVP). This certificate is valid for 10 years from the 10th day after vaccination and is required to enter certain countries.

• People ages 9+ traveling to countries that require proof of yellow fever vaccination
• People ages 9+ traveling to parts of South America and Africa where the risk of yellow fever is known to exist
• Laboratory personnel or anyone who may have been exposed to the yellow fever virus
• Children ages 6 months and under
• Anyone with moderate or severe illness should wait until they recover to be vaccinated
• People with an allergy or hypersensitivity to eggs, chicken and gelatin
• People who are pregnant or plan to become pregnant and nursing mothers
• People shouldn’t get this vaccine if they have a weakened immune system for any reason, including:
• HIV/AIDS or another disease that affects the immune system
• Taking medications that weaken the immune system
• Treatment with steroids, such as prednisone, for 2 weeks or longer
• People with cancer or undergoing cancer treatment
• People with history of thymus disease, including myasthenia gravis, thymoma or prior removal of thymus gland
• Those who previously had a severe, life-threatening allergic reaction to the vaccine or any ingredient in the vaccine
• People who have received another live vaccine within the last 4 weeks

Mild-to-moderate side effects:

• Soreness, redness or swelling at the injection site
• Fever, headache and muscle aches

Severe side effects, although rare, may include serious allergic reactions. Symptoms include:

• Severe nervous system reactions
• Life-threatening illness with major organ system failure
• Difficulty breathing
• Fast heartbeat

Over-the-counter pain relievers such as acetaminophen or ibuprofen can help ease pain and reduce fever. Contact your doctor or pharmacist if you have any unexpected or worsening reactions after receiving a vaccine.

If you believe you have a medical emergency, please call 911 .

References:

Overview - Yellow fever

Yellow fever is a serious infection spread by mosquitoes. It's found in certain areas of Africa and South and Central America. You should have a yellow fever vaccination if you're travelling to an area where there's a risk of getting it.

Check if you're at risk of yellow fever

You can get yellow fever if you're bitten by an infected mosquito. The mosquitoes that carry the yellow fever virus bite during the day.

Yellow fever is very common in certain parts of the world, including:

• parts of sub-Saharan Africa (the area below the Sahara desert)
• parts of South America, including Trinidad and Tobago
• parts of Central America

Yellow fever is not found in the UK, Europe, Asia, Australia, New Zealand or the Pacific Islands.

Check before you travel

You can get health advice for a country you're travelling to on the TravelHealthPro website

How to lower your risk of yellow fever

If you're travelling to an area where yellow fever is found, there are some things you can do to avoid being bitten by mosquitoes.

Do wear long-sleeved clothing and trousers to cover your arms and legs, particularly during early morning and early evening use insect repellent on your skin (ideally one that contains the ingredient DEET) close windows and doors whenever possible, or use blinds or screens sleep under a mosquito net treated with insecticide, including during the day Yellow fever vaccination

The yellow fever vaccine is recommended if:

• you're travelling to an area where yellow fever is found
• you need a yellow fever certificate to prove you've been vaccinated

Some people at risk of yellow fever through their work should also get vaccinated.

The yellow fever vaccine is safe for most people who are 9 months old or over.

You have to pay for the yellow fever vaccine for travel, and you can only get it from registered yellow fever vaccination centres.

Find out more about the yellow fever vaccine

Yellow fever vaccination centres

Find your nearest yellow fever vaccination centre on the National Travel Health Network and Centre website

Symptoms of yellow fever

Yellow fever symptoms usually start 3 to 6 days after being bitten by an infected mosquito, but sometimes they can take longer to appear.

Some yellow fever symptoms are similar to flu, such as:

• high temperature
• feeling or being sick
• aches and pains
• loss of appetite
• feeling generally unwell

These symptoms often last 3 or 4 days. But a small number of people get more serious symptoms within 24 hours of feeling better.

More serious symptoms include:

• yellowing of your skin and eyes ( jaundice )
• stomach pain
• bleeding from your eyes, nose, mouth or stomach – you may have blood in your vomit or poo

These more serious symptoms can be fatal.

Urgent advice: Ask for an urgent GP appointment or get help from NHS 111 if:

• you feel unwell after travelling to a country where yellow fever is found

You can call 111 or get help from 111 online .

Tell anyone you speak to about your recent travel, and if you were bitten by a mosquito or might have been.

If you become unwell while you're abroad, get medical help as soon as possible. Do not wait until you get back to the UK.

Treatment for yellow fever

There's no specific treatment for yellow fever.

Most people make a full recovery after 3 or 4 days.

Things you can do to help ease your symptoms include:

• taking painkillers, such as paracetamol or ibuprofen , which can help lower your temperature and relieve muscle pain or backache
• drinking plenty of fluids to avoid dehydration

If you have more serious symptoms of yellow fever, you'll need to go into hospital immediately to be treated.

Page last reviewed: 25 July 2023 Next review due: 25 July 2026

Australian Government Department of Health and Aged Care

Yellow fever fact sheet

This fact sheet is for travellers to Africa, the Caribbean, and Central or South America. It includes information about yellow fever, vaccination requirements, biosecurity border measures and the yellow fever vaccination certificate.

Scroll down to access downloads and media.

Download [Publication] Yellow fever fact sheet (PDF) as PDF - 221.31 KB - 7 pages

Download [Publication] Yellow fever fact sheet (Word) as Word - 138.75 KB - 7 pages

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Yellow Fever VIS

Current Edition Date: 4/1/2020

• Print VIS [2 pages]
• RTF file [4 pages] (For use in electronic systems)
• VIS in other languages
• More information about yellow fever vaccination

Yellow Fever Vaccine: What You Need to Know

• Why get vaccinated?
• Yellow fever vaccine
• Talk with your health care provider
• Risks of a vaccine reaction
• What if there is a serious problem?
• How can I learn more?

Yellow fever vaccine can prevent yellow fever . Yellow fever is a serious disease caused by the yellow fever virus. There is no medicine to treat or cure yellow fever.

Yellow fever virus is spread by the bite of an infected mosquito. It is found in parts of Africa and South America.

The majority of people with yellow fever virus infections will either not have symptoms, or have mild disease and completely recover. But some people will develop severe disease.

Symptoms and signs of yellow fever include:

• Sudden onset of fever and chills
• Headache, back pain, or general body aches
• Nausea or vomiting

More severe symptoms of yellow fever can include:

• Jaundice (yellow skin or eyes)
• Bleeding from multiple body sites
• Shock (life-threatening condition in which the body is not getting enough blood flow)
• Liver, kidney, or other organ failure

Severe yellow fever can cause death in 30% to 60% of affected people.

In addition to getting vaccinated, you can also protect yourself from yellow fever by avoiding mosquito bites:

• Use insect repellent
• Wear long-sleeved shirts and long pants
• Stay in well-screened or air-conditioned areas

Yellow fever vaccine is a live vaccine containing weakened, live yellow fever virus. It is given as a single shot. One dose provides lifelong protection for most people.

Yellow fever vaccine is recommended for:

• P eople 9 months through 59 years of age who are traveling to or living in areas at risk for yellow fever virus activity, or traveling to a country with an entry requirement for vaccination. (People younger than 9 months or older than 59 years who are at increased risk might receive yellow fever vaccine in some situations. Ask your health care provider for more information.)
• Laboratory personnel who might be exposed to yellow fever virus or vaccine virus.

Yellow fever vaccine is given only at designated vaccination centers. After getting the vaccine, you will be given an “International Certificate of Vaccination or Prophylaxis” (ICVP, sometimes called the “yellow card”). You will need this card as proof of vaccination to enter certain countries. If you don’t have it, you might be required to get yellow fever vaccine upon entering the country, or be forced to wait for up to 6 days to make sure you are not infected.

Do not donate blood for 14 days after vaccination, because there is a risk of passing vaccine virus to others during that period.

Discuss your itinerary with your health care provider before you get your yellow fever vaccination. You can visit CDC’s Travelers’ Health website at https://wwwnc.cdc.gov/travel  to learn if yellow fever vaccination is recommended or required based on your travel location.

Tell your vaccine provider if the person getting the vaccine:

• Has had an allergic reaction after a previous dose of yellow fever vaccine, or has any severe, life-threatening allergies .
• Has a weakened immune system.
• Has had their thymus removed or been diagnosed with a thymus disorder .
• Is pregnant or
• Has gotten any other vaccines in the past 4 weeks .

People with minor illnesses, such as a cold, may be vaccinated. People who are moderately or severely ill should usually wait until they recover before getting yellow fever vaccine.

In some cases, your health care provider may decide to postpone yellow fever vaccination to a future visit.

If you cannot get yellow fever vaccine for medical reasons and you are traveling to a country with a yellow fever vaccination entry requirement, your doctor will need to fill out the Medical Contraindications to Vaccination section of your yellow card. In addition, your doctor should give you a waiver letter. If you plan to use a waiver, you can contact the embassies of countries you plan to visit for more information.

• Soreness, redness, or swelling where the shot was given are common after yellow fever vaccine.
• Fever sometimes happens.
• Headache and muscle aches can occur.
• Nervous system reactions such as inflammation of the brain (encephalitis) and/or spinal cord covering (meningitis), or Guillain-Barré Syndrome (GBS), among others.
• Life-threatening severe illness with organ dysfunction or failure.

People 60 years and older and people with weakened immune systems might be more likely to experience serious reactions to yellow fever vaccine.

People sometimes faint after medical procedures, including vaccination. Tell your provider if you feel dizzy or have vision changes or ringing in the ears.

As with any medicine, there is a remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death.

An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 and get the person to the nearest hospital.

For other signs that concern you, call your health care provider.

Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your health care provider will usually file this report, or you can do it yourself. Visit the VAERS website  or call 1-800-822-7967 .  VAERS is only for reporting reactions, and VAERS staff do not give medical advice.

• Ask your health care provider.
• Call your local or state health department .
• Call 1-800-232-4636 ( 1-800-CDC-INFO ) or
• Visit CDC’s Yellow Fever website

Many vaccine information statements are available in Spanish and other languages. See www.immunize.org/vis

Hojas de información sobre vacunas están disponibles en español y en muchos otros idiomas. Visite www.immunize.org/vis

Vaccine Information Statement Yellow Fever Vaccine (4/1/20)

Department of Health and Human Services Centers for Disease Control and Prevention

Office Use Only

• Vaccines & Immunizations
• Immunization Schedules

Exit Notification / Disclaimer Policy

• The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
• Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
• You will be subject to the destination website's privacy policy when you follow the link.
• CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.

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• Yellow Fever Vaccination
• Passengers travelling to and from YF endemic countries (countries where Yellow Fever disease is persisting) are required to be in possession of a “VALID YELLOW FEVER VACCINATION CERTIFICATE” issued by authorized and designated vaccination centers in India.
• Those found not in possession of such Valid certificate or defective certificate as enumerated by the WHO, are upon reporting by the Immigration Officers are quarantined for a period till the YF certificate becomes “valid” or until a period of six days, reckoned from the date of last possible exposure to infection, has elapsed, whichever occurs first.
• All vaccine beneficiaries have to wait for 30 minutes after receiving the vaccination and
• Inform immediately to the doctor on duty in case of any uneasiness, side effects, rashes , reaction or any other adverse event.

Who should not get yellow fever vaccine?

• Anyone with allergy to eggs, chicken proteins, or gelatin,
• who had a severe allergic reaction to a previous dose of Yellow fever vaccine (Tell your doctor if you have any severe allergies)
• You are pregnant, or could be pregnant now or in the next two weeks
• Children younger than 09 months of age,
• HIV/AIDS patient.
• Immune system is weakened as a result of cancer or other medical conditions, a transplant, or radiation or drug treatment (such as steroids or cortisone, cancer chemotherapy, or other drugs that affect immune cell function).
• Persons with acute/moderate illness (with or without a fever) should postpone receiving this vaccine until they are well.
• Patients with thymus disorder, such as myasthenia gravis, DiGeorge syndrome, or thymoma or Thymus removed.
• Patients with major liver or kidney disease
• Nursing mothers should avoid or postpone travel to an area where there is risk of yellow fever.
• Adults 60 years of age and older might be at increased risk for severe problems following vaccination.

Mild Side Effects of Vaccination

• Yellow fever vaccine has been associated with fever and with aches, soreness, redness or swelling where the shot was given. These problems occur in up to 1 out of 4 persons. They usually begin soon after the shot, and can last up to a week.
• Most people may have a slight sore arm.
• 2-10% may feel tired, headache, muscle aches, fever for 24 hours starting 3-9 days after the vaccine
• 1% need to curtail regular activities

More Serious Side Effects of Vaccination

• The risk of a vaccine causing serious harm, or death, is extremely low.
• Severe allergic reaction to a vaccine component (about 1 person in 55,000).
• Severe nervous system reaction (about 1 person in 125,000).
• Life-threatening severe illness with organ failure (about 1 person in 250,000). More than half the people who suffer this side effect die. The last two complications have never been reported with a booster dose.
• 1 in 130,000 will get immediate hypersensitivity – rash, itching faint or asthma – this is why you need to wait 30 minutes in the clinic
• 0.09-2.5 per million will get inflammation of multiple organs e.g. lungs, kidney, liver, spleen, skin, blood stream
• 1 in 8 million will get encephalitis (inflammation of the brain)

What if there is a severe reaction? What should we look for?

• Look for any unusual condition, such as a high fever, behavior changes, or flu-like symptoms
• Signs of an allergic reaction can include difficulty in breathing, hoarseness or wheezing, hives, paleness, weakness, a fast heart¬beat, or dizziness within a few minutes to a few hours after the shot.

What should we do?

• Call a doctor, or get the person to a doctor right away.
• Tell the doctor what happened, the date and time it happened, and when the vaccination was given.
• Keep informed the APHO, about any adverse reaction and treatment/hospital details.
• This certificate is valid only if the vaccine or prophylaxis has been approved by the World Health Organization.
• This certificate must be signed in hand of the clinician who shall be a medical practitioner or other authorised health worker, supervising the administration of vaccine or prophylaxis. The certificate must also bear the official stamp of administering centre; however, this shall not be an accepted substitute for the signature.
• Any amendment of this certificate, or erasure, or failure to complete any part of it, may render it invalid.
• The validity of this certificate is life of person vaccinated i.e. for whole life. The certificate shall be fully completed in English or in French. The certificate may also be completed in another language on the same document, in addition to either English or French.

Passengers planning to travel to or passing through any of the Yellow Fever endemic country even while seated within the aircraft, are required to have the vaccination and in possession of VALID YELLOW FEVER CERTIFICATE in Original at all times, complete in all respects as per standards laid down by the WHO in its Regulations.

Since the Vaccine is developed and prepared in Chick Embryo, anyone having Allergy to Egg protein must not take the vaccination, as it is likely to lead to severe anaphylactic reaction, which could be fatal. Besides this other absolute contradictions are deficient immunity in individuals under medication for Thymus disease, Cancer, HIV/AIDS, on Corticosteroids for any reasons, suffering from any severe allergies. Those suffering from severe Asthmatic conditions should also avoid taking this vaccination.

The vaccination is valid after 10 days from the date of vaccination and duration of its validity is the life of the person vaccinated.

Vaccination Procedure

• Yellow Fever Vaccination received in India is valid only if it is received from Govt. of India recognized centers only.
• 10 PERSONS ARE REQUIRED IN A BATCH (As the vaccine available vial is of 10 dose each & it is opened only when 10 persons are available)
• FEE - RS.300/- FOR ONE VACCINE, fixed by Govt. of India from time to time.
• There has to be gap of four weeks between two different live vaccines.
• The vaccination services are to be provided as first come first served basis.
• The registration / token distribution system may be followed to maintain the first come first serve system.
• At time of registration, the Travel Document (passport) is to be checked and all the vaccinees are instructed to read the necessary information regarding Yellow Fever Vaccination displayed in the registration / waiting area.
• The vaccinees are informed to bring/keep the Travel Document (passport) and the vaccination fee Rs.300/- with them at the vaccination time.
• All the vaccinees are instructed to wait in the waiting area and the vaccinees are called for vaccination in batches of 10 persons in vaccination room.
• All the vaccinees are informed and allowed to read about the side effects / adverse reactions and other related information about Yellow Fever Vaccination.
• The informed consent is to be taken from all the vaccinees.
• The entries are filled up in the vaccination register from Travel Document (passport) & subsequently the fee for the vaccination is collected and the receipt for the same is given to vaccinee.
• The vaccinees are directed to complete the entries related to vaccine in WHO Yellow Fever Vaccination card and directed for vaccine inoculation.
• Checks the Vial Viability Marker.
• The required amount of diluents mixed in the vial with 5ml disposable plastic syringe.
• All the bio-medical waste are segregated and collected/disposed in the respective bags at the time of procedure only as per biomedical waste rules.
• The water swab is used to clean the inoculation area.
• The vaccination dose i.e. 0.5ml for everybody is inoculated to the vaccinee with 1ml disposable/AD plastic syringe.
• After inoculation the vaccinees are asked to wait for 30 minutes and inform about any side effects / adverse reactions to doctor on duty.

Yellow Fever Vaccine is an attenuated, live-virus preparation of the 17D strain of yellow fever virus grown in leucosis-free chick embryos. A single dose correctly given confers immunity in 100% of recipients. Protective immunity is achieved only after 10 days of yellow fever vaccination and persists till life of person vaccinated. This vaccine is given as a single injection given subcutaneously. Yellow fever Vaccination Certificate becomes valid only after 10 days of vaccination.

Yellow Fever Endemic Countries – the list is updated on 03 January 2023 by WHO

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Search for Yellow Fever Vaccination Clinics

Click a state, choose from a list of states and territories, search by zip code.

Frequently Asked Questions about the U.S. Yellow Fever Vaccination Center Registry

State Yellow Fever Coordinators can update information for an authorized yellow fever vaccine provider/center.

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Exit Notification / Disclaimer Policy

• The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
• Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
• You will be subject to the destination website's privacy policy when you follow the link.
• CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.